GLP-1 agonists such as Mounjaro and Wegovy® were originally developed to treat type 2 diabetes, but in recent years, they’ve gained widespread attention for a different reason: supporting significant weight loss.
These medications work by mimicking a hormone called glucagon-like peptide-1 (GLP-1), which helps regulate:
• Appetite
• Insulin secretion
• Glucose metabolism
The result? You feel fuller for longer, have fewer cravings, and are more in control of your eating—especially helpful during midlife, when metabolism slows and managing weight becomes increasingly challenging.
How GLP-1 Agonists Support Weight Loss
GLP-1 medications like Wegovy and Mounjaro help:
• Reduce appetite and hunger
• Slow gastric emptying (helping you feel full)
• Improve insulin sensitivity
This mechanism makes them a valuable tool in midlife weight management, particularly during menopause, when hormonal changes often lead to weight gain around the abdomen.
Important Considerations Before Starting GLP-1 Therapy
While these medications can be incredibly helpful, there are several important things to know:
1. They’re Not Subsidised by the PBS for Weight Loss
Unless you have type 2 diabetes or specific medical criteria, GLP-1 agonists are not currently subsidised by the PBS in Australia. This means an out-of-pocket cost ranging from $130 to $400 per month.
2. They Require Ongoing Use
GLP-1 medications need to be taken long term to maintain weight loss. Stopping the medication without consistent lifestyle changes such as dietary improvements and regular strength training can often result in weight regain.
3. They Work Best with a Holistic Approach
These aren’t magic pills. They work best when paired with:
• A personalised nutrition plan
• Strength-based exercise
• Medical guidance and regular reviews
This combined, evidence-based approach offers the best long-term results.
Are GLP-1 Agonists Right for You?
GLP-1 agonists aren’t suitable for everyone. Side effects, contraindications, and personal health history all need to be carefully considered. That’s why these medications should always be discussed in a personalised consultation with your healthcare provider.
For women in perimenopause and menopause, these medications may be part of a broader plan to improve metabolic health, energy levels, and quality of life but only as one tool in a well-rounded, medically supervised strategy.
Final Thoughts
If you’re struggling with midlife weight gain, it’s not just about willpower. Hormonal shifts, stress, and metabolic changes all play a role. GLP-1 medications like Mounjaro and Wegovy may offer support, but they’re most effective when used alongside healthy habits and with professional oversight.
Need help deciding if GLP-1 therapy is right for you?
Book a consultation to explore safe, evidence-based options tailored to your unique stage of life.
